{"id":2,"date":"2025-01-25T14:18:44","date_gmt":"2025-01-25T14:18:44","guid":{"rendered":"https:\/\/vdjlab.com\/?page_id=2"},"modified":"2025-02-06T23:20:56","modified_gmt":"2025-02-06T23:20:56","slug":"preclinicaltesting","status":"publish","type":"page","link":"https:\/\/vdjlab.com\/index.php\/preclinicaltesting\/","title":{"rendered":"Preclinical testing\u200b"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2\" class=\"elementor elementor-2\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0c2c9ab e-con-full e-flex e-con e-parent\" data-id=\"0c2c9ab\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4525868 elementor-widget elementor-widget-heading\" data-id=\"4525868\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Preclinical testing<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8b2b254 e-con-full e-flex e-con e-parent\" data-id=\"8b2b254\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-e615615 e-flex e-con-boxed e-con e-child\" data-id=\"e615615\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-edee287 elementor-widget elementor-widget-text-editor\" data-id=\"edee287\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">We welcome collaborations to evaluate promising pharmacological compounds using our mouse models of Parkinson\u2019s Disease. Below is a summary of our prior successful partnerships.<\/span><\/p><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Michael C, H Bock, I Serrano, B Bechand,\u00a0DJ Vidyadhara\u2026\u2026 SS Chandra, J McCorvy, D Sames. Pharmacological mechanism of the non-Hallucinogenic 5-HT2A agonist Ariadne and analogs,\u00a0<\/span><i><span style=\"font-weight: 400;\">ACS Chemical Neuroscience<\/span><\/i><span style=\"font-weight: 400;\">,\u00a02022,\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1021\/acschemneuro.2c00597\"><span style=\"font-weight: 400;\">https:\/\/doi.org\/10.1021\/acschemneuro.2c00597<\/span><\/a><\/li><\/ul><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">SN Suresh, J Pandurangi, R Murumalla,\u00a0DJ Vidyadhara, L Garimella, A Acharya, S Rai, A Paul, H Yarreiphang, M S Pillai, M Giridharan, JP Clement, PA Alladi, T Saiyed, R Manjithaya, \u00a0Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration,\u00a0<\/span><i><span style=\"font-weight: 400;\">The Lancet EBioMedicine<\/span><\/i><span style=\"font-weight: 400;\">,\u00a02019,\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1016\/j.ebiom.2019.10.036\"><span style=\"font-weight: 400;\">https:\/\/doi.org\/10.1016\/j.ebiom.2019.10.036<\/span><\/a><\/li><\/ul><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Suresh SN, Aravinda C, Malini P, Veena A,\u00a0DJ Vidyadhara, H Yarreiphang, Shashank Rai, Abhik Paul, James P Clement, Alladi PA, Ravi. M. Modulation of autophagy by a small molecule inverse agonist of ERR\u03b1 is neuroprotective.\u00a0<\/span><i><span style=\"font-weight: 400;\">Frontiers in Molecular Neuroscience<\/span><\/i><span style=\"font-weight: 400;\">,\u00a02018,\u00a0<\/span><a href=\"https:\/\/doi.org\/10.3389\/fnmol.2018.00109\"><span style=\"font-weight: 400;\">https:\/\/doi.org\/10.3389\/fnmol.2018.00109<\/span><\/a><\/li><\/ul><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Suresh S.N., Aravinda C,\u00a0Vidyadhara DJ, Yarrei H, \u2026\u2026, Ravi. M. A novel autophagy modulator 6-Bio ameliorates SNCA\/\u03b1-synuclein toxicity.\u00a0<\/span><i><span style=\"font-weight: 400;\">Autophagy<\/span><\/i><span style=\"font-weight: 400;\">,\u00a02017,\u00a0<\/span><a href=\"https:\/\/doi.org\/10.1080\/15548627.2017.1302045\"><span style=\"font-weight: 400;\">https:\/\/doi.org\/10.1080\/15548627.2017.1302045<\/span><\/a><\/li><\/ul><p><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Preclinical testing We welcome collaborations to evaluate promising pharmacological compounds using our mouse models of Parkinson\u2019s Disease. Below is a summary of our prior successful partnerships. Michael C, H Bock, I Serrano, B Bechand,\u00a0DJ Vidyadhara\u2026\u2026 SS Chandra, J McCorvy, D Sames. Pharmacological mechanism of the non-Hallucinogenic 5-HT2A agonist Ariadne and analogs,\u00a0ACS Chemical Neuroscience,\u00a02022,\u00a0https:\/\/doi.org\/10.1021\/acschemneuro.2c00597 SN Suresh, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-2","page","type-page","status-publish","hentry"],"_hostinger_reach_plugin_has_subscription_block":false,"_hostinger_reach_plugin_is_elementor":false,"_links":{"self":[{"href":"https:\/\/vdjlab.com\/index.php\/wp-json\/wp\/v2\/pages\/2","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vdjlab.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/vdjlab.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/vdjlab.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vdjlab.com\/index.php\/wp-json\/wp\/v2\/comments?post=2"}],"version-history":[{"count":45,"href":"https:\/\/vdjlab.com\/index.php\/wp-json\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":2229,"href":"https:\/\/vdjlab.com\/index.php\/wp-json\/wp\/v2\/pages\/2\/revisions\/2229"}],"wp:attachment":[{"href":"https:\/\/vdjlab.com\/index.php\/wp-json\/wp\/v2\/media?parent=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}