{"id":10,"date":"2025-01-25T15:25:22","date_gmt":"2025-01-25T15:25:22","guid":{"rendered":"https:\/\/vdjlab.com\/home\/"},"modified":"2025-09-29T19:36:22","modified_gmt":"2025-09-29T19:36:22","slug":"home","status":"publish","type":"page","link":"https:\/\/vdjlab.com\/","title":{"rendered":"Home"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"10\" class=\"elementor elementor-10\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8a7839b e-con-full e-flex e-con e-parent\" data-id=\"8a7839b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;slideshow&quot;,&quot;background_slideshow_gallery&quot;:[{&quot;id&quot;:2056,&quot;url&quot;:&quot;https:\\\/\\\/vdjlab.com\\\/wp-content\\\/uploads\\\/2025\\\/02\\\/for-id-1-scaled.jpg&quot;},{&quot;id&quot;:2057,&quot;url&quot;:&quot;https:\\\/\\\/vdjlab.com\\\/wp-content\\\/uploads\\\/2025\\\/02\\\/for-id-2-scaled.jpg&quot;}],&quot;background_slideshow_slide_transition&quot;:&quot;slide_up&quot;,&quot;background_slideshow_slide_duration&quot;:2,&quot;background_slideshow_transition_duration&quot;:57000,&quot;background_slideshow_ken_burns&quot;:&quot;yes&quot;,&quot;background_slideshow_ken_burns_zoom_direction&quot;:&quot;out&quot;,&quot;background_slideshow_loop&quot;:&quot;yes&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-283f602 elementor-widget elementor-widget-heading\" data-id=\"283f602\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">.<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eb451eb elementor-widget elementor-widget-heading\" data-id=\"eb451eb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Unravel the mechanisms of synaptic and axonal degeneration in Parkinson\u2019s disease and aging, and translate these insights\nto promote brain health across the lifespan!<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fe7df41 elementor-widget elementor-widget-text-editor\" data-id=\"fe7df41\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h1 style=\"display: inline-block; color: #ffff; font-size: 50px; animation: bounce 1s infinite ease-in-out; position: relative;\">\u00a0<\/h1><p><style>\n  @keyframes bounce {<br \/>    0%, 100% { transform: translateY(0); }<br \/>    50% { transform: translateY(10px); }<br \/>  }<br \/><\/style><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-aaea429 e-grid e-con-boxed e-con e-parent\" data-id=\"aaea429\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-66f89a8 e-con-full e-flex e-con e-child\" data-id=\"66f89a8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7abf70b elementor-widget elementor-widget-heading\" data-id=\"7abf70b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Why?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eeb5849 elementor-widget elementor-widget-text-editor\" data-id=\"eeb5849\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Upright walking, unique to humans, freed our hands and fueled our cognition, but also brought about distinctive movement disorders like Parkinson\u2019s disease.<\/p><p>Now the world\u2019s fastest-growing neurological disorder, Parkinson\u2019s affects over 10 million people globally, primarily among the aging population, with about 1 million in the U.S.<\/p><p>In light of its significant impact, the U.S. government has initiated a National Plan to End Parkinson\u2019s, a goal that hinges on our understanding of the disease\u2019s underlying mechanisms.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6eece09 e-con-full e-flex e-con e-child\" data-id=\"6eece09\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-349011c elementor-widget elementor-widget-heading\" data-id=\"349011c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">What?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cabc3d1 elementor-widget elementor-widget-text-editor\" data-id=\"cabc3d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Neurodegenerative processes in Parkinson&#8217;s disease arise from an interplay between aging and genetic\/environmental factors. The primary sites of degeneration are dopamine-producing neurons in the nigrostriatal network of brain.<\/p><p>While it is established that synapses of these neurons degenerate before the cell bodies, the mechanisms behind this synaptic degeneration and its role in the overall disease process remain unclear.<\/p><p>Our lab aims to address this gap by studying novel Parkinson&#8217;s-related mutations in presynaptic endolysosomal proteins, examining how these mutations interact with genetic and environmental risk factors, as well as aging.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3464152 e-con-full e-flex e-con e-child\" data-id=\"3464152\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b1e36f5 elementor-widget elementor-widget-heading\" data-id=\"b1e36f5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">How?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-95990cd elementor-widget elementor-widget-text-editor\" data-id=\"95990cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Our team is pursuing this goal through three comprehensive studies that integrate mechanistic investigations using mouse models, patient-derived and CRISPRed iPSC neurons, SH-SY5Y cell lines, and patient biospecimens.<\/p><p>We will employ a diverse range of advanced techniques in histopathology, microscopy, biochemistry, subcellular proteomics, mouse behavior, viral gene manipulations, and various cell biology methods.<\/p><p>Additionally, we will collaborate on electrophysiological studies and utilize C. elegans models to further investigate our research questions, while also partnering with clinicians to translate our findings to benefit those affected.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>. Unravel the mechanisms of synaptic and axonal degeneration in Parkinson\u2019s disease and aging, and translate these insights to promote brain health across the lifespan! \u00a0 Why? Upright walking, unique to humans, freed our hands and fueled our cognition, but also brought about distinctive movement disorders like Parkinson\u2019s disease. Now the world\u2019s fastest-growing neurological disorder, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"plain-container","ast-site-content-layout":"full-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"enabled","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-10","page","type-page","status-publish","hentry"],"_hostinger_reach_plugin_has_subscription_block":false,"_hostinger_reach_plugin_is_elementor":false,"_links":{"self":[{"href":"https:\/\/vdjlab.com\/index.php\/wp-json\/wp\/v2\/pages\/10","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vdjlab.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/vdjlab.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/vdjlab.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vdjlab.com\/index.php\/wp-json\/wp\/v2\/comments?post=10"}],"version-history":[{"count":163,"href":"https:\/\/vdjlab.com\/index.php\/wp-json\/wp\/v2\/pages\/10\/revisions"}],"predecessor-version":[{"id":2298,"href":"https:\/\/vdjlab.com\/index.php\/wp-json\/wp\/v2\/pages\/10\/revisions\/2298"}],"wp:attachment":[{"href":"https:\/\/vdjlab.com\/index.php\/wp-json\/wp\/v2\/media?parent=10"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}