Publications
DJ Vidyadhara, David Bäckström, Risha Chakraborty, Jiapeng Ruan, Jae-Min Park, Pramod K. Mistry, Sreeganga. S. Chandra. Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson’s disease and Dementia with Lewy bodies.
bioRxiv, 2024
DJ Vidyadhara, M. Somayaji, N. Wade, B. Yucel, H. Zhao…., Dalibor Sames, Lois Greene, David Sulzer, and Sreganga S. Chandra. Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease.
Cell Reports, 2023
Xi Cheng, Yu Tang, DJ Vidyadhara, Ben-Zheng Li, M. Zimmerman, A Pak, A Klug, SS Chandra, A Chubykin. Impaired Presynaptic Plasticity, Visual Mismatch Negativity, and Familiarity-Evoked Oscillations in Auxilin Knockout Mice, Cell iScience, 2023
EM Lopez, DJ Vidyadhara, T Liberia, SJ. M, LE. Harmon, RM. Hsu, K Han, B Yücel, SS Chandra, CA Greer. α-Synuclein pathology and reduced neurogenesis in the olfactory system affect olfaction in a mouse model of Parkinson’s disease. Journal of Neuroscience, 2023
Yarreiphang H, DJ Vidyadhara, AN Nambi, Raju TR, C Sagar, Alladi PA. Apoptotic factors and mitochondrial complexes assist determination of strain-specific susceptibility of mice to Parkinsonian neurotoxin MPTP. Molecular Neurobiology, 2023
S. Massaro Tieze, SS. Chandra, DJ Vidyadhara. Subcellular Fractionation for the Isolation of Synaptic Components from the Murine Brain. J. of Visualized Experiments (JoVE), 2022
Michael C, H Bock, I Serrano, B Bechand, DJ Vidyadhara…… SS Chandra, J McCorvy, D Sames. Pharmacological mechanism of the non-Hallucinogenic 5-HT2A agonist Ariadne and analogs. ACS Chemical Neuroscience, 2023
CS Boddupalli, S Nair, G Belinsky, J Gans, E Teeple, T Nguyen, S Mehta, L Guo, M Kramer, J Ruan, M Davison, DJ Vidyadhara, B Zhang, K Klinger, Pramod Mistry. Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells. eLife, 2022
DJ Vidyadhara, Yarreiphang H, Raju TR, Alladi PA. Differences in neuronal numbers, morphology and developmental apoptosis in mice nigra provide experimental evidence of ontogenic origin of vulnerability to Parkinson’s disease. Neurotoxicity Research, 2021
SN Suresh, J Pandurangi, R Murumalla, DJ Vidyadhara, L Garimella, A Acharya, S Rai, A Paul, H Yarreiphang, M S Pillai, M Giridharan, JP Clement, PA Alladi, T Saiyed, R Manjithaya, Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration, The Lancet EBioMedicine, 2019
DJ Vidyadhara, A Sasidharan, BM Kutty, TR Raju, PA Alladi. Admixing MPTP-resistant and MPTP-vulnerable mice enhances striatal field potentials and calbindin-D28K expression to avert motor behaviour deficits, Behavioural brain research, 2019
DJ Vidyadhara, JE Lee, SS Chandra. Role of the endolysosomal system in Parkinson’s disease, Journal of neurochemistry, 2019
Ravi M, Senthilkumar S, Popa-Wagner A, P U, Ram K, Guruprasad KP, DJ Vidyadhara. Pluchea lanceolata protects hippocampal neurons from endothelin-1 induced ischemic injury to ameliorate cognitive deficits. J. of Chemical Neuroanatomy, 2018
Suresh SN, Aravinda C, Malini P, Veena A, DJ Vidyadhara, H Yarreiphang, Shashank Rai, Abhik Paul, James P Clement, Alladi PA, Ravi. M. Modulation of autophagy by a small molecule inverse agonist of ERRα is neuroprotective. Frontiers in Molecular Neuroscience, 2018
Ravi M, Senthilkumar S, Padmaja U, DJ Vidyadhara, Suchitra P, Basavaiah R. Neuroprotective functions of Alpinia galanga in forebrain ischemia induced neuronal damage and oxidative insults in rat hippocampus, Indian Journal of Pharmaceutical Education and Research, 2018
DJ Vidyadhara, Yarre. H, Raju TR, Alladi PA. Admixing of MPTP-Resistant and Susceptible Mice Strains Augments Nigrostriatal Neuronal Correlates to Resist MPTP-Induced Neurodegeneration. Molecular Neurobiology, 2017
Suresh S.N., Aravinda C, Vidyadhara DJ, Yarrei H, ……, Ravi. M. A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity. Autophagy, 2017
G Sivakumar, DJ Vidyadhara, KN Shivananda, T Rajesh, K G Mohandas Rao, Kiranmai S Rai. Prophylactic choline supplementation attenuates vascular cognitive impairment in rodent model of ischemic stroke. Indian Journal of Physiology & Pharmacology, 2017
DJ Vidyadhara, Yarreiphang H, Abhilash PL, Raju TR, Alladi PA.. Role of nigral dopaminergic neuronal calbindin in determining the differential susceptibility of mice strains to MPTP. J. of Chem. Neuroanatomy, 2016
Jyothi HJ * , Vidyadhara DJ*, Anita M, M Philip, Suresh K, G Manoh, Shankar SK, Raju TR, Alladi PA. Aging causes morphological alterations in astrocytes and microglia in human substantia nigra pars compacta. Neurobiology of Aging, 2015 ( * contributed equally)
G Sivakumar, DJ Vidyadhara, S Reddy, T Rajesh, R Babu, Mohandas Rao, Kiranmai S Rai. Prophylactic combined supplementation of choline and docosahexaenoic acid attenuates vascular cognitive impairment and preserves hippocampal cell viability in a rat model of chronic cerebral hypoperfusion ischemic brain injury, Int. Jou. of Basic & Clinical Pharmacology, 2015