Preclinical testing
We welcome collaborations to evaluate promising pharmacological compounds using our mouse models of Parkinson’s Disease. Below is a summary of our prior successful partnerships.
- Michael C, H Bock, I Serrano, B Bechand, DJ Vidyadhara…… SS Chandra, J McCorvy, D Sames. Pharmacological mechanism of the non-Hallucinogenic 5-HT2A agonist Ariadne and analogs, ACS Chemical Neuroscience, 2022, https://doi.org/10.1021/acschemneuro.2c00597
- SN Suresh, J Pandurangi, R Murumalla, DJ Vidyadhara, L Garimella, A Acharya, S Rai, A Paul, H Yarreiphang, M S Pillai, M Giridharan, JP Clement, PA Alladi, T Saiyed, R Manjithaya, Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration, The Lancet EBioMedicine, 2019, https://doi.org/10.1016/j.ebiom.2019.10.036
- Suresh SN, Aravinda C, Malini P, Veena A, DJ Vidyadhara, H Yarreiphang, Shashank Rai, Abhik Paul, James P Clement, Alladi PA, Ravi. M. Modulation of autophagy by a small molecule inverse agonist of ERRα is neuroprotective. Frontiers in Molecular Neuroscience, 2018, https://doi.org/10.3389/fnmol.2018.00109
- Suresh S.N., Aravinda C, Vidyadhara DJ, Yarrei H, ……, Ravi. M. A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity. Autophagy, 2017, https://doi.org/10.1080/15548627.2017.1302045